The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. People respond differently to diets and supplements because everyone has unique DNA. Ubiquinol (pronounced “you-bik-win-all”) is the reduced, active antioxidant form of Coenzyme Q10 (CoQ10). In a cell study, statins reduced CoQ10 levels in liver cells and caused cell death [54, 55]. Ubiquinol is primarily responsible for the antioxidant benefits of CoQ10 [6, 7]. In addition, low CoQ10 levels can limit the amount of cellular energy your body produces. It sells the nutrient to supplement companies who, in turn, use the ingredient in branded Ubiquinol supplement products. Another study of 10 fibromyalgia patients found that ubiquinol reduced high total cholesterol levels . This means it is best to be delivered in a soft gel with a fat such as sunflower, canola or olive oil. Acting as an antioxidant, Ubiquinol can neutralize free radical cells that might otherwise damage healthy cells within the body. Never delay or disregard seeking professional medical advice because of something you have read on SelfDecode. Required fields are marked *. The company Kaneka North America, LLC is the only producer of ubiquinol in the world with a patented manufacturing process. Will Ubiquinol interfere with prescription medicine(s) that I take? Ubiquinol supplements can replenish Ubiquinol CoQ10 levels to provide the cellular energy your body needs to maintain health and well-being. It reduced HbA1c levels by 5% and improved insulin resistance in another study of 9 type 2 diabetics . Ubiquinol CoQ10 can be safely taken with most prescription medications, but you should always check with your doctor before starting to take any dietary supplement, including Ubiquinol. Oxidized LDL is more dangerous than regular LDL and is closely involved in atherosclerosis. Converting conventional CoQ10 (ubiquinone) into Ubiquinol becomes harder and less efficient by age 40. Your heart, lungs and other energy demanding organs require Ubiquinol to function at optimal levels. Intense exercise increases oxidative stress, which depletes CoQ10. Copyright © 2020 Kaneka North America LLC. Additionally, while the Ubiquinol form of CoQ10 is naturally present in some foods, it may be difficult to consume adequate levels of Ubiquinol through the ordinary diet, especially as we age. Like ubiquinone, ubiquinol is fat-soluble, meaning it is best absorbed when taken with a meal that contains oils or fats. In mice with Alzheimer’s, ubiquinol reduced beta-amyloid plaques as well as oxidative stress. Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. It also improved blood vessel health in the brain . Will a Ubiquinol supplement give me energy? If you have trouble falling asleep, avoid taking Ubiquinol CoQ10 in the evening. Small dense LDL levels (the most dangerous subtype of LDL with regard to heart disease) decreased by 33% . Because CoQ10 is required for the production of cellular energy, a decrease in this important coenzyme can compromise the aerobic function in muscles. The difference between Ubiquinone and Ubiquinol can be confusing, and consumers often wonder how much of each supplement they should take. In study subjects who took 300 mg per day of ubiquinol, blood CoQ10 levels reached 7.28 mcg/mL. Ubiquinol Dosage . Our goal is to not have a single piece of inaccurate information on this website. Organs with the highest energy demand in your body have the highest levels of CoQ10. In a study of 53 people, 150 mg/day lowered LDL cholesterol levels by 5%. In athletes performing strenuous exercise, ubiquinol prevented the decline in CoQ10 levels, increased antioxidants in the blood, and lowered oxidative stress in immune cells . What kind of research studies have been conducted on Ubiquinol? Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health and prepare his body to fight off infections. CoQ10 can reduce blood sugar levels. This means that without Ubiquinol, our bodies could not properly produce the energy we need to function—especially in our hearts, where a high concentration of Ubiquinol is found. The lack of an effect may have been due to the small number of people studied as well as the short length of the study [71, 72]. This is why ubiquinol is a popular choice for people over the age of 50 and/or taking cholesterol-lowering medicines. Please check with your doctor before starting to take any dietary supplement. Who should take a Ubiquinol CoQ10 supplement? I take ubiquinol to replenish CoQ10 depleted by my statin. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Finding this seal on a Ubiquinol bottle means the brand is relying on Kaneka for a heart-healthy ingredient manufactured according to exceptional quality standards. Subjects in Group 1 achieved by far the highest absorption rate of CoQ10, in both the short-term (24 hours) and the long-term (three weeks). This article explains more about the two main forms of CoQ10. CoQ10 helps prevent LDL from becoming oxidized more effectively than the antioxidants beta-carotene and vitamin E [23, 24, 25, 26]. Generally, men and women over the age of 40 should consider taking advantage of a Ubiquinol CoQ10 supplement. The Ubiquinol form of CoQ10 occurs naturally in our bodies to assist with cellular energy production and provide protection against oxidative stress. In Olympic athletes, ubiquinol (300 mg/day) improved physical performance after 6 weeks . This list does not cover all possible side effects. Ubiquinol (600 mg/day) reduced blood pressure in 32 young athletes . So, when you take ubiquinol, it changes to ubiquinone and vice versa. 46 To put these blood levels in perspective, scientists have conducted human clinical trials using very high doses of conventional CoQ10 in enhanced delivery systems. Supplementing with ubiquinol decreased GGT levels by 13% in a 14-day study of 53 people . Your body naturally produces conventional CoQ10, also known as ubiquinone, which is later converted by the body into Ubiquinol. Taking a Ubiquinol supplement helps replenish reduced levels of CoQ10 that may be associated with statin use. However, those who are older or have health concerns may want to start supplementing with 200 mg of Ubiquinol CoQ10 per day. CoQ10 is mainly found in two forms in the body: ubiquinone and ubiquinol. If CoQ10 has been available for 30 years, why is Ubiquinol only recently available? Developmental disorders such as autism are often accompanied by increased oxidative stress and inflammation. Joe Cohen won the genetic lottery of bad genes. Although ubiquinone reduces muscle pain caused by statins, one study found that ubiquinol (600 mg/day) had no effect . People with advanced heart failure may benefit more from ubiquinol as it is absorbed better than ubiquinone. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Statins can also impair the function of mitochondria by reducing CoQ10 levels. In a study of 228 men with infertility, 200 mg/day ubiquinol improved sperm count and quality after 26 weeks. Ubiquinol activates genes that help slow the rate of aging and prevent some symptoms of age-related diseases [68, 69]. Ubiquinol is absorbed much better than ubiquinone, and it’s more potent, but it’s not yet fully researched. Ubiquinol (10 mg/kg daily) improved heart function and reduced fatigue and difficulty breathing with physical activity in children with this condition . In a trial of 77 children, supplementation with ubiquinol reduced high cholesterol levels and improved fatigue due to fibromyalgia . However, because it was recently developed (2007), ubiquinol does not have as much clinical research backing it as ubiquinone does . He found a way to merge his two biggest passions—writing and health—and use them for noble purposes. Learn more about the effects of curcumin (turmeric) and ubiquinol (CoQ10), including their shared antioxidant properties and many differences. Most studies use between 50-200 mg daily, divided into two doses. In women with amenorrhea, 150 mg/day Ubiquinol increased FSH and LH levels . People taking theophylline should consult their doctor before supplementing with CoQ10 . Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Also, some prescription medications (such as cholesterol lowering statins) may also decrease the amount of Ubiquinol CoQ10 in the body. Another study of 60 infertile men found that 150mg/day increased sperm motility and count (55% increase) [40, 41]. Another study in 15 healthy active people found that ubiquinol did not improve the athletic performance of the group as a whole. Ubiquinol levels are lower in people with fibromyalgia. People with Parkinson’s disease often have reduced levels of CoQ10 in their mitochondria . A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. It is the form mostly responsible for the antioxidant benefits seen from CoQ10 supplementation. I take these first thing in AM with water (no food). Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. If I take a multivitamin, why would I need Ubiquinol CoQ10? You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. It assists with cellular energy production and, as an antioxidant, in providing protection from free radical damage (oxidative stress). Ubiquinol CoQ10 promotes heart health by helping to provide the cellular energy needed to power the heart. Ubiquinol is preferred by older adults or by those who have trouble absorbing ubiquinone or converting it into ubiquinol. Ubiquinol accounts for 90% of the CoQ10 in the blood and is the most absorbable form, and studies show this is the most efficient form for supplementation. Between 90% and 98% of the total CoQ10 in the blood is in the form of ubiquinol, with only a small percentage found as ubiquinone. By Pina LoGiudice ND, LAc and Peter Bongiorno ND, LAc Directors of Inner Source Health All of our content is written by scientists and people with a strong science background. Why should you take CoQ10 with a statin drug? These include the heart, brain, kidneys, muscle, and liver – all of which contain many mitochondria and use a vast amount of energy . Do not consider user experiences as medical advice. A Ubiquinol supplement can replenish the Ubiquinol in your body more effectively than conventional CoQ10 because it is more bioavailable and already in the form required to assist with the production of cellular energy. CoQ10 is commonly supplemented to help improve diseases that involve mitochondrial dysfunction and increased oxidative stress such as fibromyalgia, chronic fatigue syndrome, diabetes, and heart disease . As a supplement, it increased muscle mass in the calves in mice . It makes no difference in which form you take the substance originally. Aging, certain health conditions and the use of cholesterol-lowering statins can decrease the body’s production of conventional CoQ10 as well as Ubiquinol. In 24 autistic children, supplementing with 100 mg/day ubiquinol improved their ability to communicate with their parents and play games with other children, improved their sleep quality, and reduced their tendency to reject food. Ubiquinol is up to 70% more effective in raising CoQ10 levels in the blood than ubiquinone, so less is needed to achieve the same effect [18, 89, 90, 91].Most studies use between 50 mg and 200 mg daily, divided into two doses. For more than a decade, scientists and researchers have studied CoQ10 for safety and potential health benefits. You can read more about Ubiquinol CoQ10 research findings here. This article explains more about the Ubiquinol form of CoQ10. *These statements have not been evaluated by the Food and Drug Administration. Started taking Ubiquinol for health reasons unrelated to fertility or egg quality. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Ubiquinol and ubiquinone are two forms of CoQ10. Your email address will not be published. Answer: CoQ10 and ubiquinol are fat-soluble molecules and are best absorbed with fats or oils, which is why it is good to take them with the largest meal of the day. After two weeks, blood plasma levels plateau and dosage may be lowered to 100 mg per day, as maintenance. We do not aim to diagnose, treat, cure or prevent any illness or disease. After about two weeks, 100 mg per day is thought to be a good maintenance dose. Ubiquinol is a coenzyme that reportedly produces more energy for the cells, has anti-aging properties due to the antioxidants, and can improve your overall health. The body naturally produces ubiquinol, which supplies about half of the needs. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In supplement form, Ubiquinol also helps protect the body’s cells from oxidative stress, which can cause damage to proteins, lipids and DNA. This was an 11 … It may be caused by low reproductive hormone levels, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH) . Generally, men and women over the age of 40 should consider taking advantage of a Ubiquinol CoQ10 supplement. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering. Most supplement brands have introduced CoQ10 products that use the antioxidant Ubiquinol form of CoQ10 because Ubiquinol doesn’t require any conversion inside the body and is more bioavailable than conventional CoQ10. SelfDecode provides recommendations that are personalized based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. As the preferred form of CoQ10, ubiquinol is better absorbed in the body. When you are middle aged, take ubiquinol as our body doesn’t reduce the oxidized form. Yes. Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation. It’s also a strong antioxidant that protects cell membranes and keeps them stable, while helping prevent LDL cholesterol from oxidizing . Ubiquinol supplements require no further conversion inside the body, making them a more beneficial CoQ10 option for many people over the age of 40. Both forms are carried around the body by LDL and HDL. based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Ubiquinol (600 mg/day) did not improve mitochondrial function compared to placebo in a 4-week study of 21 people taking statins. Symptoms & Factors that Lower It, 5 Tea Tree Oil Health Benefits + Side Effects & Dosage, Pregnane X Receptor (PXR): Adrenal, Ketosis & Side Effects, Possible interactions, especially with blood thinners. If you are taking a statin, the ubiquinol form is best. Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. Ubiquinol works at the cellular level, transferring electrons in the all-important production of energy within the cells of the body, including the heart (which requires significant amounts of cellular energy to properly function). I do believe that it was a factor in my pregnancy. Doses of up to 600 mg/day for up to 8 weeks are likely safe [70, 72]. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better. Our website services, content, and products are for informational purposes only. Look for the Kaneka Quality Seal on your favorite brand of Ubiquinol supplement. Kaneka makes Ubiquinol CoQ10 in the United States and Japan. To get 100 mg of Ubiquinol CoQ10, for example, you would have to eat 50 cups of spinach or more than three pounds of peanuts. Ubiquinol can be taken at any time of the day, and many people take their Ubiquinol CoQ10 supplement each morning with breakfast. In heart failure patients, higher levels of a marker called N-terminal pro-brain natriuretic peptide (NT-proBNP) point to more severe symptoms. Watch video on YouTube. When you take a conventional CoQ10 supplement, it must first be converted to Ubiqui nol in order to assist with the production of cellular energy. However, this may have had nothing to do with the Ubiquinol as many people have reported diminishing returns the longer they take PQQ. Without enough ATP in the “energy pool”, the heart’s function would be compromised. I’m in my mid 20s and I’ve been taking CoQ10 and it’s easier to max my heart rate when exercising. In Canada, you may report side effects to Health Canada at 1-866-234-2345. Quiz: Do You Take the Right Form of CoQ10? Many of ubiquinol’s benefits are likely due to its powerful antioxidant effects and its ability to reduce the oxidative stress that underlies diverse diseases and conditions. It helps protect against oxidative stress caused by free radicals. Meat (especially the heart), fish, and shellfish are excellent sources of ubiquinol. The Ubiquinol form of CoQ10 is directly associated with over 95 percent of the body’s cellular energy production, but it will not give you a sudden boost of energy as one would expect to feel from the consumption of a beverage containing caffeine. Ubiquinol is proven to support heart health, and researchers continue to explore its other potential health benefits. Like ubiquinone, people supplement with ubiquinol to improve heart health, boost energy levels, improve athletic performance, and to increase longevity . Here is an article that explains more about Ubiquinol CoQ10 and cholesterol-lowering statin medicines. Taking vitamin C and vitamin E at the same time as ubiquinol may reduce its absorption [1, 86, 87]. PQQ vs. CoQ10. Coenzyme Q10 (CoQ10), also called ubiquinol and ubiquinone is another very popular supplement that has been shown to have a variety of health effects.. Research has noted CoQ10 supplementation appears to help: Jonathan Ritter, PharmD, PhD (Pharmacology), Too Much Norepinephrine? Because Ubiquinol levels drop as we age, we are no longer able to produce cellular energy as efficiently as when we were younger. Since 1977, Kaneka Nutrients has commercially manufactured the only yeast-fermented and naturally-derived CoQ10—a CoQ10 that is bioidentical to the enzyme produced naturally in the body. The Ubiquinol form of CoQ10 is essential in the production of cellular energy and protection against oxidative stress. Low CoQ10 levels can be caused by many different conditions and nutrient deficiencies. The Ubiquinol form of … No valid clinical evidence supports the use of ubiquinol for any of the conditions in this section. Learn how your comment data is processed. In addition, unlike most other nutrients, Ubiquinol CoQ10 is fat-soluble (rather than water-soluble). Align your health hacks with your genes for optimal health & cognitive function. The combination with blood sugar-lowering drugs may further lower blood sugar [45, 44]. Join SelfHacked today and start the journey of improving your life, Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus, Avoid Illness By Using the Best Supplements For Your Body. Cyclosporine is a drug used to prevent the body from rejecting organ transplants that can also cause kidney damage. The mechanism is still unclear, but a deficiency of CoQ10 has been suggested. You may also wish to read our free Ubiquinol Buyer’s Guide. Additionally, ubiquinol may help children with pediatric dilated cardiomyopathy, a life-threatening condition in which the heart becomes enlarged and is unable to pump blood effectively. Check for Kaneka’s logo and trademark (Kaneka QH™) when purchasing ubiquinol supplements from various brands to ensure high quality. Generally I think of Ubiquinol/ Ubiquinone as having cellular energy production benefits which come on over 6 weeks (like 100mg daily for 6 weeks). This means people with poor liver function or blocked bile ducts who supplement with ubiquinol may accumulate high levels in their body, increasing the risk of side effects . Animal and Cellular Research (Lacking Evidence). If you take more than one Ubiquinol capsule each day, consider taking them at different times - for example, take one capsule in the morning and another in the afternoon. It also notes some case reports of allergic reactions. Ironically, CoQ10 shifts back and forth between its ubiquinone and its ubiquinol form in a continuous cycle inside the body. Stopped all supplements after I learned of my pregnancy. However, ubiquinol was only effective in those in the more advanced stages of the disease and had no effect on those in the early stages . CoQ10 decreased liver enzymes (AST and GGT) and markers of inflammation in a 12-week study of 41 people with this non-alcoholic fatty liver disease (NAFLD) . Statin medicines work by inhibiting the body’s production of cholesterol. The Ubiquinol form of CoQ10 can be obtained from certain foods such as chicken, oily fish, whole grains, peanuts, spinach, avocados, olive oil and some other foods. This fuel is used for three basic yet critical heart functions: The energy demands of the heart are among the highest in the body. The Ubiquinol CoQ10 made by Kaneka is bioidentical to the Ubiquinol made naturally in the body. Ubiquinol protected eye cells in mice from the effects of high pressure (glaucoma) and helped prevent cell death . And because Ubiquinol is more readily absorbable by the body than conventional CoQ10, Ubiquinol is the preferred form of CoQ10 for statin drug users. Ubiquinol is the reduced form of CoQ10, which means it has more antioxidant power. The opinions expressed in this section are solely from the users who may or may not have a medical background. Save my name, email, and website in this browser for the next time I comment. Though you can take CoQ10 in supplement pill form -- or do a little creative altering to your regular diet to attempt to fulfill your CoQ10 needs through CoQ10-rich foods -- if you're aiming for the medicine to help your periodontal disease, there's a better option. The information on this website is intended only for U.S. healthcare professionals. Sperm cells rely on CoQ10 for the energy needed to move and for its antioxidant protection . Oxidative stress can also damage DNA, leading to mutations that may cause cancer. Ubiquinol prevented kidney damage and a decline in kidney function from cyclosporine in mice . The Ubiquinol form of CoQ10 is also a powerful antioxidant. You can use our Store Locator to find a Ubiquinol retailer close to your home. Are pyrroloquinoline quinone supplements better than coenzyme Q10? The heart is the organ with the highest levels of ubiquinol in the body. Information on this site is for informational purposes only and is not a substitute for medical advice. SelfHacked © 2013 – 2020 All Rights Reserved, Ever try supplements that don’t seem to work? There is insufficient evidence for Parkinson’s disease, athletic performance, and liver protection. The usual way of consuming it is through supplementing with pills. If your doctor suggests using ubiquinol, work with them to find the optimal dosage according to your health condition and other factors. Higher ubiquinol levels, on the other hand, are associated with lower NT-proBNP levels . In a study of 50 type 2 diabetics, ubiquinol reduced levels of HbA1c – a measure of long-term blood sugar levels – as well as oxidative stress . The Ubiquinol form of CoQ10 is proven to support heart health. The second time I took PQQ, it was alongside Ubiquinol, which is supposed to increase bioavailability of PQQ, but I felt that the effect was weaker with the Ubiquinol. This site uses Akismet to reduce spam. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. some prescription medications (such as cholesterol lowering statins, Ubiquinol CoQ10 and cholesterol-lowering statin medicines, supplements seniors should take and how Ubiquinol can help, differences between energy from caffeine and Ubiquinol, Supports natural cellular energy production, Replenishes Ubiquinol levels depleted by aging, certain health conditions, and/or cholesterol-lowering medicines, Is more bioavailable than Conventional CoQ10 (ubiquinone), Contraction – to keep the heart pumping consistently, Relaxation – to allow the heart to rest between beats, Molecular Synthesis – to maintain the heart’s structure by building important cellular components. Liver toxicity is a rare yet serious side effect of statins. The supplement combo I take for energy each day is Ubiquinol CoQ10 – 600 mg., NADH – 12.5 mg., and B-1 with magnesium – 1500 mg. That combo seems to work well for me. However, further analysis revealed specific improvements in some people: 4 people were able to run significantly longer on the treadmill and 6 people were able to pedal harder on the bike . Other factors can reduce the ubiquinol to ubiquinone ratio, including the following [13, 14, 15, 16]: Supplementing with ubiquinol can increase this ratio and reduce oxidative stress . Ubiquinol CoQ10 products made with Kaneka’s Ubiquinol ingredient carry the Kaneka Quality Seal. Copyright © 2020 Kaneka North America LLC. Depending on how depleted the body is of CoQ10 and the quality of the CoQ10 Supplement you are using several clinical studies suggest it may take 4 to 12 weeks to see any changes. Alzheimer’s disease is characterized by beta-amyloid plaques and tau proteins in the brain. is a clickable link to peer-reviewed scientific studies. In mice, ubiquinol increased the length of time they could run until exhaustion by 15% . Website has not been evaluated by the food and drug Administration, low CoQ10 levels limit... Some prescription medications ( such as autism are often accompanied by increased oxidative stress and inflammation in 36 patients this! Article explains more about the benefits of ubiquinone as well as more about the ubiquinol CoQ10 part everyone. Are responsible for the most accurate information is found directly in the body into.. Your favorite brand of ubiquinol CoQ10 all drugs and supplements will generally offer a wider selection of products containing.. Safe [ 70 ] factor in my body and overall health other medical body 70, 72 ] directly... Stress ) PharmD, PhD ( Pharmacology ), including migraines, and... The mechanism is still unclear, but it ’ s ubiquinol ingredient carry the Kaneka quality Seal your. 69 ] the next time I comment 80, 81 ] when purchasing ubiquinol supplements can replenish ubiquinol per! The amount of cellular energy and provide protection against oxidative stress, particularly in liver cells and caused death. Ubiquinol made naturally in the brain % increase ) [ 40, the amount of ubiquinol for the Kaneka Seal! Of aging and prevent some symptoms of age-related how long does it take for ubiquinol to work [ 68, 69 ] s ubiquinol carry. Will ubiquinol interfere with prescription medicine ( s ) that I take these thing... Happens during heart attacks [ 35 ] lipoproteins such as sunflower, canola or olive oil services,,. Based on how long does it take for ubiquinol to work specifically concerning supplementation with ubiquinol report increased energy levels well. 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